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Precision-cut Lung Slices (PCLS) have been instrumental in studying the body's innate responses to viral and, to a lesser extent, bacterial challenges. This system has shed light on which cells become infected within the intact lung, offering insights distinct from in vitro air-liquid interface cultures. [25]
The encoded protein is a calcium-dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial ...
Circulating endothelial cells (CECs) are endothelial cells that have been shed from the lining of the vascular wall into the blood stream. [1] Endothelial cells normally line blood vessels to maintain vascular integrity and permeability, but when these cells enter into the circulation, this could be a reflection of vascular dysfunction and damage. [2]
PECAM-1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte transmigration, angiogenesis , and integrin activation. [ 5 ]
Human lung microvascular endothelial cells (HLMVECs) are cells derived from the pulmonary endothelium. HLMVECs are used as a laboratory model system for the study of the function and pathology of the pulmonary endothelium to research conditions such as ARDS [ 1 ] HLMVECs are used due to their simple techniques for isolating them from adult ...
These include cell adhesion, migration, invasion, proliferation, differentiation, and endothelial cell tube formation. [3] EHS tumor-derived matrices, such as Cultrex BME, are used for a variety of cell culture applications, including angiogenesis, [ 4 ] spheroid formation, organoid culture, pluripotent stem cell culture, xenograft , and in ...
The Lund protocol utilises a roller pump, blood-based perfusate, and an ECMO ventilator. Red blood cells account for 14% of the Steen perfusate–that is, haematocrit level is kept at 14%. [14] The Lund protocol achieves a complete target flow, which is 100% of the cardiac output.
When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface. Thrombin is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca 2+ -independent pathway involved in ...