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Omega-3-acid ethyl esters are used in addition to changes in diet to reduce triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia. [3] In the European Union and other major markets outside the US, omega-3-acid ethyl esters are indicated for hypertriglyceridemia by itself, or in combination with a statin for people with mixed dyslipidemia.
Ethyl eicosapentaenoic acid (E-EPA) was the second fish-oil drug to be approved, after omega-3-acid ethyl esters (GlaxoSmithKline's Lovaza, which was approved in 2004. [31] [7] [32]) Initial sales were not as robust as Amarin had hoped. The labels for the two drugs were similar, but doctors prescribed Lovaza for people who had triglycerides ...
There are other omega−3 fish oil based drugs on the market that have similar uses and mechanisms of action. [8] Omega−3-acid ethyl esters (brand names Omarcor or Lovaza, [9] Omtryg, [10] and as of March 2016, four generic versions). [11] Ethyl eicosapentaenoic acid (Vascepa, and 1 generic as ethyl icosapent) [12]
Hemp is high in fiber, antioxidants, and omega-3 fatty acids. It may help reduce cholesterol and protect against cardiovascular disease , but more human research is needed.
Intake of large doses (2.0 to 4.0 g/day) of long-chain omega−3 fatty acids as prescription drugs or dietary supplements are generally required to achieve significant (> 15%) lowering of triglycerides, and at those doses the effects can be significant (from 20% to 35% and even up to 45% in individuals with levels greater than 500 mg/dL).
People in the 592 HbA1c trials had a mean age of 58.9 years (42.3% female), and for the 23 trials that reported major adverse cardiovascular events, the mean age was 64 years (35.3% female).
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