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Esomeprazole's successful predecessor, omeprazole, is a mixture of two mirror-imaged molecules (esomeprazole which is the S-enantiomer, and R-omeprazole); critics said the company was trying to "evergreen" its omeprazole patent by patenting the pure esomeprazole and aggressively marketing to doctors that it is more effective than the mixture.
Naproxen/esomeprazole, sold under the brand name Vimovo, is a pain reliever medication in the form of a tablet for oral consumption, containing naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and a delayed release formulation of esomeprazole, a stomach acid–reducing proton-pump inhibitor (PPI). [2] [3] It is produced by AstraZeneca. [4]
"Esomeprazole 40 mg twice daily for triple therapy may improve the H. pylori eradication compared to omeprazole-based therapy, but only for homologous extensive metabolizers of CYP2C19." The paper is Sheu et al. 2005 Aliment Pharmacol Ther v21, pp.283-88 (doi: 10.1111/j.1365-2036.2005.02281.x), but it is probably behind a paywall.
AstraZeneca also developed esomeprazole (Nexium) which is a eutomer, purely the (S)-enantiomer, rather than a racemate like omeprazole. [medical citation needed] Omeprazole undergoes a chiral shift in vivo which converts the inactive (R)-enantiomer to the active (S)-enantiomer, doubling the concentration of the active form. [59]
Traditional Vietnamese medicine (Y học Cổ truyền Việt Nam), also known as Southern Herbology (Thuốc Nam) is a traditional medicine practiced by Vietnamese people.
The GI cocktail generally contains a mixture of viscous lidocaine, an antacid, and an anticholinergic. [ 1 ] [ 2 ] The GI cocktail is commonly prescribed in the hospital or emergency department, and has been used to help distinguish chest pain as either gastrointestinal or cardiac. [ 1 ]
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