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Flux is the net movement of particles across a specified area in a specified period of time. [1] The particles may be ions or molecules, or they may be larger, like insects, muskrats or cars. The units of time can be anything from milliseconds to millennia. Flux is not the same as velocity or speed nor is it the same as density or concentration.
In biochemistry, metabolic flux (often referred to as flux) is the rate of turnover of molecules through a metabolic pathway. Flux is regulated by the enzymes involved in a pathway. Within cells , regulation of flux is vital for all metabolic pathways to regulate the pathway's activity under different conditions. [ 1 ]
Fluxomics describes the various approaches that seek to determine the rates of metabolic reactions within a biological entity. [1] While metabolomics can provide instantaneous information on the metabolites in a biological sample, metabolism is a dynamic process. [2]
The flux control coefficient, instead, measures how much influence a given step has on the steady-state flux. A step with a high flux control coefficient means that changing the activity of the step (by changing the expression level of the enzyme) will have a large effect on the steady-state flux through the pathway and vice versa.
Metabolic flux analysis (MFA) is an experimental fluxomics technique used to examine production and consumption rates of metabolites in a biological system. At an intracellular level, it allows for the quantification of metabolic fluxes , thereby elucidating the central metabolism of the cell. [ 1 ]
Flux (biology), movement of a substance between compartments; Flux (metabolism), the rate of turnover of molecules through a metabolic pathway; 4-Fluoroamphetamine (4-FA; PAL-303; "Flux"), a central nervous system stimulant with quasi-amphetamine effects; Dysentery, or other diseases called "flux", which cause the loss of fluid by diarrhea or ...
Print/export Download as PDF; Printable version; In other projects Wikidata item; ... Flux (biology), movement of a substance between compartments;
Although flux control is shared, this doesn't imply that control is evenly distributed. For a large network, the average flux control will, according to the flux summation theorem, be equal to /, that is a small number. In order for a biological cell to have any appreciable control over a pathway via changes in gene expression, some ...