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Cystatin C is a non-glycosylated, basic protein (isoelectric point at pH 9.3). The crystal structure of cystatin C is characterized by a short alpha helix and a long alpha helix which lies across a large antiparallel, five-stranded beta sheet. Like other type 2 cystatins, it has two disulfide bonds.
The functions of the kidney include maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules; regulation of blood pressure; production of various hormones, such as erythropoietin; and activation of vitamin D.
One of these is cystatin C, a ubiquitous protein secreted by most cells in the body (it is an inhibitor of cysteine protease). [15] Cystatin C is freely filtered at the glomerulus. After filtration, Cystatin C is reabsorbed and catabolized by the tubular epithelial cells, with only small amounts excreted in the urine.
Bill Clinton is one proud grandpa!. On Monday, Nov. 25, the former President of the United States, 78, appeared on an episode of Live with Kelly and Mark and spoke about how he and the former ...
Pores in one of the structures of the glomerular filtration barrier. Shrunken pore syndrome (SPS) is a kidney disorder described in 2015 in which the pores in the glomerular filtration barrier are hypothesized to have shrunken so that the glomerular filtration rate (GFR) of 5–30 kDa proteins, for example cystatin C, is selectively reduced compared to that of small molecules (less than 5 kDa ...
An endangered orca vanished from a dwindling whale pod off the Washington coast, a conservation group said. The missing Southern Resident killer whale, K-26, was not seen by researchers during an ...
"Try to see the good in people." "Come on − he can't be that bad." "You should be grateful to even be in a relationship.". If you've heard these phrases before, chances are you've been "bright ...
Interpretation [ edit ] In the United States and in most European countries creatinine is usually reported in m g / d L , whereas in Canada, Australia, [ 23 ] and a few European countries, such as the UK, μ mol / L is the usual unit.
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