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Functions of a healthy kidney include maintaining a person's fluid balance, ... The normal range of GFR, adjusted for body surface area, is 100–130 average 125 ...
The normal range of GFR, adjusted for body surface area, is 100–130 average 125 mL/min/1.73m 2 in men and 90–120 ml/min/1.73m 2 in women younger than the age of 40. In children, GFR measured by inulin clearance is 110 mL/min/1.73 m 2 until 2 years of age in both sexes, and then it progressively decreases. After age 40, GFR decreases ...
Algorithms to estimate GFR from creatinine concentration and other parameters are discussed in the renal function article. Unfortunately, the MDRD Study equation was developed in people with chronic kidney disease, and its major limitations are imprecision and systematic underestimation of measured GFR (bias) at higher/normal values. [20]
Dialysis is a treatment that substitutes for the function of normal kidneys. Dialysis may be instituted when approximately 85%–90% of kidney function is lost, as indicated by a glomerular filtration rate (GFR) of less than 15.
It reflects one aspect of kidney function, how efficiently the glomeruli – the filtering units – work. The normal GFR is >90 ml/min. The units of creatinine vary from country to country, but since the glomeruli comprise <5% of the mass of the kidney, the GFR does not indicate all aspects of kidney health and function.
Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney. This encompasses all functions of the kidney, including maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules ...
GFR on its own is the most common and important measure of renal function. However, in conditions such as renal artery stenosis, blood flow to the kidneys is reduced. Filtration fraction must therefore be increased in order to perform the normal functions of the kidney. Loop diuretics and thiazide diuretics decrease filtration fraction.
The standard definition of a reference range for a particular measurement is defined as the interval between which 95% of values of a reference population fall into, in such a way that 2.5% of the time a value will be less than the lower limit of this interval, and 2.5% of the time it will be larger than the upper limit of this interval, whatever the distribution of these values.
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