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Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal). It is caused by the JC virus, which is normally present and kept under control by the immune system. The ...
Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [ 5 ] of the cell nucleus.
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
Berenger's original formulation is called a split-field PML, because it splits the electromagnetic fields into two unphysical fields in the PML region. A later formulation that has become more popular because of its simplicity and efficiency is called uniaxial PML or UPML , [ 5 ] in which the PML is described as an artificial anisotropic ...
A CT of leukoencephalopathy. Leukoencephalopathy (leukodystrophy-like diseases) is a term that describes all of the brain white matter diseases, whether their molecular cause is known or unknown. [1]
In promyelocytic leukemia (PML), the oncogenic PML-retinoic acid receptor alpha (RARalpha) chimera disrupts the normal concentration of PML in nuclear bodies. Administration of arsenic trioxide (As 2 O 3 ) plus all-trans retinoic acid (Tretinoin) causes remission of this leukemia by triggering the bodies' reorganization.
PML may refer to: Pakistan Muslim League, several Pakistani political parties; Partido Movimiento Libertario, libertarian political party in Costa Rica;
The Pakistan Muslim League (Quaid e Azam Group) Urdu: پاکستان مسلم لیگ (ق); Pākistān Muslim Līg (Qāf), Acronyms: PML(Q), PML-Q, PMLQ, "Q League" (officially registered as the Pakistan Muslim League) [5] is a political party in Pakistan. As of the 2024 parliamentary election, it has a representation of five seats.