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An odds ratio (OR) is a statistic that quantifies the strength of the association between two events, A and B. The odds ratio is defined as the ratio of the odds of event A taking place in the presence of B, and the odds of A in the absence of B. Due to symmetry, odds ratio reciprocally calculates the ratio of the odds of B occurring in the presence of A, and the odds of B in the absence of A.
The case control study can, however, calculate the exposure-odds ratio, which, mathematically, is supposed to approach the relative risk as prevalence falls. Sander Greenland showed that if the prevalence is 10% or less, the disease can be considered rare enough to allow the rare disease assumption. [ 2 ]
In practice the odds ratio is commonly used for case-control studies, as the relative risk cannot be estimated. [1] In fact, the odds ratio has much more common use in statistics, since logistic regression, often associated with clinical trials, works with the log of the odds ratio, not relative risk. Because the (natural log of the) odds of a ...
Although in classical case–control studies, it remains true that the odds ratio can only approximate the relative risk in the case of rare diseases, there is a number of other types of studies (case–cohort, nested case–control, cohort studies) in which it was later shown that the odds ratio of exposure can be used to estimate the relative ...
The odds ratio (OR) is another useful effect size. It is appropriate when the research question focuses on the degree of association between two binary variables. For example, consider a study of spelling ability. In a control group, two students pass the class for every one who fails, so the odds of passing are two to one (or 2/1 = 2).
Formula Value Absolute risk reduction : ARR CER − EER: 0.3, or 30% Number needed to treat: NNT 1 / (CER − EER) 3.33 Relative risk (risk ratio) RR EER / CER: 0.25 Relative risk reduction: RRR (CER − EER) / CER, or 1 − RR: 0.75, or 75% Preventable fraction among the unexposed: PFu (CER − EER) / CER: 0.75 Odds ratio: OR (EE / EN) / (CE ...
Also, in effect, the validity of post-test probability determined from likelihood ratio is not vulnerable to sampling bias in regard to those with and without the condition in the population sample, and can be done as a case-control study that separately gathers those with and without the condition.
The log diagnostic odds ratio can also be used to study the trade-off between sensitivity and specificity [5] [6] by expressing the log diagnostic odds ratio in terms of the logit of the true positive rate (sensitivity) and false positive rate (1 − specificity), and by additionally constructing a measure, :