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GLP-1 agonists' weight reduction effects come from a combination of peripheral effects as well as activity in the brain via the central nervous system. [17] In the brain, GLP-1 agonists reduce weight by crossing the blood-brain barrier in the brain and directly activating the satiety hormones in the ventromedial hypothalamus (Hariyanto, 2021).
Semaglutide is a glucagon-like peptide-1 receptor agonist. [14] [15] [16] The drug decreases blood sugar levels. The decrease is theorized to be caused by the mimicking of glucagon-like peptide-1 (GLP-1), an incretin. [40] It also appears to enhance growth of pancreatic beta cells, which are responsible for insulin production and release.
The discovery of GLP-1's extremely short half-life meant that it was impossible to develop into a drug. [35] [36] This caused diabetes research to shift towards other therapeutic options such as targeting the GLP-1 receptor, which then led to the development of GLP-1 receptor agonists. [35] [36]
As the GLP-1 patients in Al-Aly’s study were all veterans, with full drug coverage, their retention rate was higher—roughly 70% after a year. How the study’s results will be interpreted or ...
A new poll found that one in eight American adults had used a GLP-1 drug, with half of those people still taking the medication. GLP-1 drugs like Ozempic and Wegovy have become increasingly ...
In one review of 14 studies, researchers found GLP-1 agonists led to an average weight loss difference of 4-6.2 percent in people with diabetes versus 6.1-17.4 percent in people without diabetes ...
Different GLP-1 receptor agonists go through inactivation by dipeptidyl peptidase-4 (DPP-4) enzymes (The clinical use of GLP-1 is hampered by its short-half life in the circulation (1-2 min), because of its proteolytic degradation by the enzymes dipeptidyl peptidase-4 (DPP-4) and neutral endopeptidase).
In the intention-to-treat analysis, people treated with CagriSema lost 20.4% of their body weight over 68 weeks, versus 11.5% with cagrilintide 2.4 mg alone, 14.9% with semaglutide 2.4 mg alone, and 3.0% with placebo.
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