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Dulcolax Balance, a trade name of macrogol, an osmotic laxative Dulcolax Stool Softener, a trade name of dioctyl sodium sulfosuccinate , a common ingredient in products such as laxatives Dulcolax SP Drops, a trade name of sodium picosulfate , a stimulant laxative drug.
Sodium picosulfate is a prodrug. [5] It has no significant direct physiological effect on the intestine; however, it is metabolised by gut bacteria into the active compound 4,4'-dihydroxydiphenyl-(2-pyridyl)methane (DPM, BHPM).
Bisacodyl is an organic compound that is used as a stimulant laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of episodic and chronic constipation and for the management of neurogenic bowel dysfunction, as well as part of bowel preparation before medical examinations, such as for a colonoscopy.
Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [2] [3] [4]Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. [1]
Lactulose is used in the treatment of chronic constipation in patients of all ages as a long-term treatment. [13] The dosage of lactulose for chronic idiopathic constipation is adjusted depending on the constipation severity and desired effect, from a mild stool softener to causing diarrhea.
A suppository is a dosage form used to deliver medications by insertion into a body orifice (any opening in the body), where it dissolves or melts to exert local or systemic effects.
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A 2014 Cochrane review concluded that duloxetine is beneficial in the treatment of diabetic neuropathy and fibromyalgia but that more comparative studies with other medicines are needed. [22] The French medical journal Prescrire concluded that duloxetine is no better than other available agents and has a greater risk of side effects. [ 23 ]
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