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  2. Kharasch–Sosnovsky reaction - Wikipedia

    en.wikipedia.org/wiki/Kharasch–Sosnovsky_reaction

    The Kharasch–Sosnovsky reaction is a method that involves using a copper or cobalt salt as a catalyst to oxidize olefins at the allylic position, subsequently condensing a peroxy ester (e.g. tert-Butyl peroxybenzoate) or a peroxide resulting in the formation of allylic benzoates or alcohols via radical oxidation. [1]

  3. Stereoselectivity - Wikipedia

    en.wikipedia.org/wiki/Stereoselectivity

    In the example below the (S)-aldehyde reacts with a thiazole to form the (S,S) diastereomer but only a small amount of the (S,R) diastereomer: [6] The Sharpless epoxidation is an example of an enantioselective process, in which an achiral allylic alcohol substrate is transformed into an optically active epoxyalcohol. In the case of chiral ...

  4. Tsuji–Trost reaction - Wikipedia

    en.wikipedia.org/wiki/Tsuji–Trost_reaction

    The Tsuji–Trost reaction (also called the Trost allylic alkylation or allylic alkylation) is a palladium-catalysed substitution reaction involving a substrate that contains a leaving group in an allylic position. The palladium catalyst first coordinates with the allyl group and then undergoes oxidative addition, forming the π-allyl complex.

  5. Sharpless epoxidation - Wikipedia

    en.wikipedia.org/wiki/Sharpless_epoxidation

    The Sharpless epoxidation is viable with a large range of primary and secondary alkenic alcohols. Furthermore, with the exception noted above, a given dialkyl tartrate will preferentially add to the same face independent of the substitution on the alkene.To demonstrate the synthetic utility of the Sharpless epoxidation, the Sharpless group created synthetic intermediates of various natural ...

  6. Enantioselective synthesis - Wikipedia

    en.wikipedia.org/wiki/Enantioselective_synthesis

    Enantioselective synthesis, also called asymmetric synthesis, [1] is a form of chemical synthesis.It is defined by IUPAC as "a chemical reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecule and which produces the stereoisomeric (enantiomeric or diastereomeric) products in unequal amounts."

  7. Copper-catalyzed allylic substitution - Wikipedia

    en.wikipedia.org/wiki/Copper-catalyzed_allylic...

    The mechanism of copper-catalyzed allylic substitutions involves the coordination of copper to the olefin, oxidative addition and reductive elimination. Enantioselective versions of these reactions have been used in the synthesis of complex molecules, such as (R)-(-)-sporochnol and (S)-(-)-zearalenone.

  8. Rubottom oxidation - Wikipedia

    en.wikipedia.org/wiki/Rubottom_oxidation

    The following examples represent only a small portion of syntheses that highlight the use of the Rubottom oxidation to install an important α-hydroxy functionality. Some of the major features of the following syntheses include the use of buffered conditions to protect sensitive substrates and the diastereoselective installation of the α ...

  9. Carbonyl allylation - Wikipedia

    en.wikipedia.org/wiki/Carbonyl_allylation

    Carbonyl allylation has been employed in the synthesis of polyketide natural products and other oxygenated molecules with a contiguous array of stereocenters. For example, allylstannanation of a threose-derived aldehyde affords the macrolide antascomicin B, which structurally resembles FK506 and rapamycin, and is a potent binder of FKBP12. [12]