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Glimepiride is an antidiabetic medication within the sulfonylurea class, primarily prescribed for the management of type 2 diabetes. [ 1 ] [ 2 ] It is regarded as a second-line option compared to metformin , due to metformin's well-established safety and efficacy. [ 1 ]
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Diabetes medications have four main mechanisms of action: [citation needed] Insulin sensitization: Increased sensitivity of insulin receptors on cells leading to decreased insulin resistance, and higher effects of insulin on blood glucose levels. Stimulation of beta cells: This stimulation increases insulin secretion from beta cells of pancreas.
Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration , it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question.
There are a large number of natural products with alpha-glucosidase inhibitor action [6] [7] [1]. For example, research has shown the culinary mushroom Maitake (Grifola frondosa) has a hypoglycemic effect.
Sales on the drug dropped significantly after the story first broke in 2007, dropping from $2.5 billion in 2006 to less than $408 million in 2009 in the US. [ 75 ] In response to the rise in risk of heart attacks, the Indian government ordered GSK to suspend its research study, called TIDE, in 2010.
Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. [1] [2] It is used together with a diabetic diet and exercise.
The absolute bioavailability of lobeglitazone is about 95% in rat. [1] In human, the mean steady state clearance (CL ss /F) was 1.13 L/h across in 1 to 4 mg dose range. In the dose range, the mean half-life was 10.3 h. [2]