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Dextroamphetamine, like other amphetamines, elicits its stimulating effects via several distinct actions: it inhibits or reverses the transporter proteins for the monoamine neurotransmitters (namely the serotonin, norepinephrine and dopamine transporters) either via trace amine-associated receptor 1 (TAAR1) or in a TAAR1 independent fashion ...
Dexamyl utilized its enantiopure isomer of greater central nervous system (CNS) selectivity, dextroamphetamine, to elevate mood and suppress appetite, whereas the concomitant barbiturate was included to broadly counteract potential adverse effects from dextroamphetamine. Its name is a portmanteau of dextro- amphetamine and amyl- barbitone.
Adderall and Mydayis [11] are trade names [note 2] for a combination drug containing four salts of amphetamine.The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. [13]
The adverse side effects of amphetamine are many and varied, and the amount of amphetamine used is the primary factor in determining the likelihood and severity of adverse effects. [ 29 ] [ 41 ] Amphetamine products such as Adderall , Dexedrine, and their generic equivalents are currently approved by the U.S. FDA for long-term therapeutic use.
Eskatrol was an amphetamine weight loss agent which was removed by the U.S. Food and Drug Administration (FDA) in 1981 after its manufacturer, [1] SmithKline & French (SKF), [2] failed to prove the therapeutic effectiveness (E max) of the medication. At the time it was among the 200 most widely prescribed drugs in the United States.
Amphetamines like dextroamphetamine and dextromethamphetamine are fairly balanced NDRAs but release norepinephrine about 2- to 3-fold more potently than dopamine. [ 8 ] [ 9 ] [ 15 ] [ 22 ] However, other studies found that dextroamphetamine and dextromethamphetamine were roughly equipotent or slightly favored dopamine in terms of norepinephrine ...
Clobenzorex can be detected in urine, which can cause false positives for workplace drug screening. [7] It is one of many drugs that can cause false positives for amphetamine urine drug screening. [8] It may be differentiated from amphetamine use through testing for metabolites such as 4-hydroxyclobenzorex [9] or enantiomeric analysis. [7]
Amphetamine type stimulants can be used in the treatment of narcolepsy, a rare neurological disorder where the brain is unable to regulate the sleep-wake mechanism. [17] Amphetamines causes an increase in dopamine release, which is the proposed mechanism for its wake-promoting effect. [ 18 ]
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