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Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach. [ 1 ]
Gastric acid or stomach acid is the acidic component – hydrochloric acid of gastric juice, produced by parietal cells in the gastric glands of the stomach lining. In humans, the pH is between one and three, much lower than most other animals, but is very similar to that of carrion eating carnivores , needing protection from ingesting pathogens .
It is not secreted in adult mammals. Chief cells also produce small amounts of gastric lipase. Gastric lipase contributes little to digestion of fat. Parietal cells ("parietal" means "relating to a wall"), also known as oxyntic cells are most numerous on the side walls of the gastric glands. The parietal cells secrete hydrochloric acid (gastric ...
Parietal cells produce potent hydrochloric acid, which damages cells. Gastric chief cells produce pepsinogen, which is activated by the acid to form pepsin. Pepsin is a protease that can digest and damage stomach cells. To prevent these disastrous effects, mucus and bicarbonate ions (HCO 3 −) are secreted by the foveolar cells.
Gastric juice, containing gastric acid, is secreted from gastric glands, which are located in gastric pits. Gastric juice contains hydrochloric acid, pepsinogen and mucus. Hydrochloric acid is secreted by parietal cells, pepsinogen is secreted by gastric chief cells and mucus is secreted by mucous neck cells. [3]
Hydrochloric acid is a strong inorganic acid that is used in many industrial processes such as refining metal. The application often determines the required product quality. [25] Hydrogen chloride, not hydrochloric acid, is used more widely in industrial organic chemistry, e.g. for vinyl chloride and dichloroethane. [8]
Parts-per-million cube of relative abundance by mass of elements in an average adult human body down to 1 ppm. About 99% of the mass of the human body is made up of six elements: oxygen, carbon, hydrogen, nitrogen, calcium, and phosphorus. Only about 0.85% is composed of another five elements: potassium, sulfur, sodium, chlorine, and magnesium ...
Additional cells present include parietal cells that secrete hydrochloric acid and intrinsic factor, chief cells that secrete pepsinogen (this is a precursor to pepsin- the highly acidic environment converts the pepsinogen to pepsin), and neuroendocrine cells that secrete serotonin. [24] [citation needed]