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Involvement of the hair follicle [1] Rarely eosinophils [1] Allergic drug reaction Rarely involvement of hair follicles. [1] Frequently eosinophils [1] Lichen sclerosus: Hyperkeratosis, atrophic epidermis, sclerosis of dermis and dermal lymphocytes. [2] Erythema multiforme Lupus erythematosis Typical findings in systemic lupus erythematosus: [3]
In non-bullous cases, perivascular and interstitial neutrophils are sometimes present in the upper dermis, with damage to blood vessels An interface dermatitis with vacuolar alteration, not otherwise specified, may be caused by viral exanthems , phototoxic dermatitis , acute radiation dermatitis , erythema dyschromicum perstans , lupus ...
Often numerous plasma cells in about 1/3 of cases; Often endothelial swelling. Erythema migrans Typically a superficial and deep perivascular lymphocytic infiltrate. [22] Plasma cells are typically located at the periphery of the lesion, whereas eosinophils are in the center. [22] Kaposi’s sarcoma in patch stage
Eosinophilic dermatosis is a form of dermatosis characterized by a preponderance of eosinophils in the dermis or epidermis. [1] Although it does not always imply a specific etiology, it is still commonly used as a classification in dermatology when more information about the condition is not known.
Histology of a skin biopsy from acute phase eosinophilic cellulitis. Note findings of plentiful tissue eosinophils and flame figures at the deeper corium sections (hematoxylin & eosin, original magnification ×40). Diagnosis requires ruling out other potential causes. [1] This includes ruling out vasculitis on skin biopsy. [1]
Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, [1] [2] is a skin disease characterized by the sudden onset of fever, an elevated white blood cell count, and tender, red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination.
Eosinophilic granulomatosis with polyangiitis consists of three stages, but not all patients develop all three stages or progress from one stage to the next in the same order; [7] whereas some patients may develop severe or life-threatening complications such as gastrointestinal involvement and heart disease, some patients are only mildly affected, e.g. with skin lesions and nasal polyps. [8]
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...