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A derivative of timoprazole, omeprazole, was discovered in 1979, and was the first of a new class of drug that control acid secretion in the stomach, a proton pump inhibitor (PPI). [11] [12] Addition of 5-methoxy-substitution to the benzimidazole moiety of omeprazole was also made and gave the compound much more stability at neutral pH. [6]
In general, proton pump inhibitors are well tolerated, and the incidence of short-term adverse effects is relatively low. The range and occurrence of adverse effects are similar for all of the PPIs, though they have been reported more frequently with omeprazole. This may be due to its longer availability and, hence, clinical experience.
Print/export Download as PDF; Printable version; In other projects Wikidata item; ... Proton-pump inhibitor: Amoxicillin: Penicillin-class antibacterial:
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
1 List of Herbal cytochrome P450 Inhibitors and Inducers. 2 See also. ... Download as PDF; Printable version; In other projects ... Proton pump inhibitors (e.g ...
Azeloprazole was designed in Japan with pharmacogenomics in mind. Some drugs in the proton pump inhibitor class are metabolized by the hepatic enzyme CYP2C19.Some individuals, such as people of Japanese ancestry, are more likely to be poor CYP2C19 metabolizers; that is, their ability to metabolize certain drugs through CYP2C19 is compromised by a genetic mutation in one or both copies of the ...
It is classified as a proton pump inhibitor (PPI). [1] It was approved for use in China in 2023. [ 2 ] It is formulated as its sodium salt, anaprazole sodium, in enteric-coated tablets .
Category: Proton-pump inhibitors. 27 languages. ... Print/export Download as PDF; Printable version; In other projects
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