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Here, PIP3 has been implicated in regulating synaptic strengthening and AMPA expression, contributing to long-term potentiation. Moreover, PIP3 suppression disrupts normal AMPA expression on the neuron membrane and instead leads to the accumulation of AMPA on dendritic spines, commonly associated with synaptic depression .
Pip's command-line interface allows the install of Python software packages by issuing a command: pip install some-package-name. Users can also remove the package by issuing a command: pip uninstall some-package-name. pip has a feature to manage full lists of packages and corresponding version numbers, possible through a "requirements" file. [14]
The Python Package Index, abbreviated as PyPI (/ ˌ p aɪ p i ˈ aɪ /) and also known as the Cheese Shop (a reference to the Monty Python's Flying Circus sketch "Cheese Shop"), [2]: 8 [3]: 742 is the official third-party software repository for Python. [4] It is analogous to the CPAN repository for Perl [5]: 36 and to the CRAN repository for R.
SciPy (pronounced / ˈ s aɪ p aɪ / "sigh pie" [2]) is a free and open-source Python library used for scientific computing and technical computing. [3]SciPy contains modules for optimization, linear algebra, integration, interpolation, special functions, FFT, signal and image processing, ODE solvers and other tasks common in science and engineering.
Akt resides in the cytosol in an inactive conformation, until the cell is stimulated and it translocates to the plasma membrane. The Akt PH domain has a high affinity for second messenger PI(3,4,5)P 3, binding to it preferentially over other phosphoinositides. [11] Thus PI3K activity is essential for translocation of Akt to the membrane.
Microsoft Office 1.5 for Mac was released in 1991 and included the updated Excel 3.0, the first application to support Apple's System 7 operating system. [177] Microsoft Office 3.0 for Mac was released in 1992 and included Word 5.0, Excel 4.0, PowerPoint 3.0 and Mail Client. Excel 4.0 was the first application to support new AppleScript. [177]
Class II and III PI3Ks are differentiated from the Class I by their structure and function. The distinct feature of Class II PI3Ks is the C-terminal C2 domain. This domain lacks critical Asp residues to coordinate binding of Ca 2+, which suggests class II PI3Ks bind lipids in a Ca 2+-independent manner.
The 3D structure of several PH domains has been determined. [11] All known cases have a common structure consisting of two perpendicular anti-parallel beta sheets, followed by a C-terminal amphipathic helix. The loops connecting the beta-strands differ greatly in length, making the PH domain relatively difficult to detect while providing the ...