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For example, systemic lupus erythematosus with severe lupus nephritis may respond to pulsed cyclophosphamide. Cyclophosphamide is also used to treat minimal change disease, [8] severe rheumatoid arthritis, granulomatosis with polyangiitis, [5] Goodpasture syndrome [9] and multiple sclerosis. [10]
Cyclophosphamide is used at 500 mg per dose for 6 doses every 2 weeks over a one-month period or six 500 to 750 mg intravenous doses per square meter of body surface for 3 years to treat severe cSLE disease and as induction therapy for lupus nephritis. Patients taking these regimens may develop bone marrow suppression, susceptibility to ...
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus ... Class IV disease ... Cyclophosphamide.
The Centers for Disease Control and Prevention estimates that more than 200,000 people in the U.S. have lupus, though the Lupus Foundation of America puts the total much higher: roughly 1.5 ...
Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. [1] Symptoms vary among people and may be mild to severe. [ 1 ]
When treatment with DMARDs fails, cyclophosphamide or steroid pulse therapy is often used to stabilise uncontrolled autoimmune disease. Some severe autoimmune diseases are being treated with bone marrow transplants in clinical trials, usually after cyclophosphamide therapy has failed.
The oral drug, brepocitinib, did not meet the primary study goal of reduction in disease activity at week 52 in patients of SLE, in which the immune system that normally helps protect the body ...
Some of the substances require conversion into active substances in vivo (e.g., cyclophosphamide).. Cyclophosphamide is one of the most potent immunosuppressive substances. In small dosages, it is very efficient in the therapy of systemic lupus erythematosus, autoimmune hemolytic anemia, granulomatosis with polyangiitis, and other autoimmune diseases.