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A schematic for long bone endochondral ossification. In developing bones, ossification commences within the primary ossification center located in the center of the diaphysis (bone shaft), [5] where the following changes occur: The perichondrium surrounding the cartilage model transforms into the periosteum. During this transformation, special ...
Diagram showing stages of endochondral ossification. Endochondral ossification is the formation of long bones and other bones. This requires a hyaline cartilage precursor. There are two centers of ossification for endochondral ossification. The primary center. In long bones, bone tissue first appears in the diaphysis (middle of shaft).
The process of endochondral ossification, which converts the cartilage models into bone, begins by the twelfth week of embryonic development. At birth, ossification of much of the bone has occurred, but the hyaline cartilage of the epiphyseal plate will remain throughout childhood and adolescence to allow for bone lengthening.
A dermal bone or investing bone or membrane bone is a bony structure derived from intramembranous ossification forming components of the vertebrate skeleton, including much of the skull, jaws, gill covers, shoulder girdle, fin rays (lepidotrichia), and the shells of turtles and armadillos.
The process of intramembranous ossification starts when a small group of adjacent MSCs begin to replicate and form a small, dense cluster of cells that is called a nidus. [a] Once a nidus has been formed the MSCs within it stop replicating. At this point, morphological changes in the MSCs begin to occur: The cell body is now larger and rounder ...
Endochondral ossification occurs in long bones and most other bones in the body; it involves the development of bone from cartilage. This process includes the development of a cartilage model, its growth and development, development of the primary and secondary ossification centers , and the formation of articular cartilage and the epiphyseal ...
Endochondral ossification is the process of forming bone from cartilage and this is the usual method. This form of bone development is the more complex form: it follows the formation of a first skeleton of cartilage made by chondrocytes, which is then removed and replaced by bone, made by osteoblasts. Intramembranous ossification is the direct ...
The endocranium, the bones supporting the brain (the occipital, sphenoid, and ethmoid) are largely formed by endochondral ossification. Thus frontal and parietal bones are purely membranous. [12] The geometry of the skull base and its fossae, the anterior, middle and posterior cranial fossae changes rapidly.