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Using nicotine products during cancer treatment may be contraindicated, as nicotine may promote tumour growth, but temporary use of NRTs to quit smoking may be advised for harm reduction. [ 76 ] Nicotine gum is contraindicated in individuals with temporomandibular joint disease . [ 77 ]
The onset of these symptoms is very fast, nicotine's half-life being only two hours. [154] The psychological dependence may linger for months or even many years. Unlike some recreational drugs, nicotine does not measurably alter a smoker's motor skills, judgement, or language abilities while under the influence of the drug. Nicotine withdrawal ...
Nicotine itself, however, is addictive but not otherwise very harmful, as shown by the long history of people safely using nicotine replacement therapy products (e.g., nicotine gum, nicotine patch). [13] Nicotine increases heart rate and blood pressure and has a range of local irritant effects but does not cause cancer. [14]
"Nicotine use can increase the risk of both cancer and cardiovascular disease," he says. "Even low levels of nicotine can alter blood pressure and heart rate, which in the long run have adverse ...
This does not, however, eliminate any harm to health caused by the nicotine itself. Current research focuses on possible long-term side effects of nicotine on blood pressure, hypertension, and possible risk of pancreatic cancer due to tobacco-specific nitrosamines (TSNAs).
It concluded that data is insufficient "to conclude that nicotine causes or contributes to cancer in humans, but there is evidence showing possible oral, esophageal, or pancreatic cancer risks". [218]: 116 However, a 2014 study suggested that vaping may be a risk factor for lung cancer. [68]
The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
The FDA recently announced a plan that would force tobacco companies to dramatically decrease levels of the highly-addictive substance in cigarettes.