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Diphenhydramine is a potent antimuscarinic (a competitive antagonist of muscarinic acetylcholine receptors) and, as such, at high doses can cause anticholinergic syndrome. [71] The utility of diphenhydramine as an antiparkinson agent is the result of its blocking properties on the muscarinic acetylcholine receptors in the brain.
Bruxism can be subdivided into two types based upon when the parafunctional activity occurs – during sleep ("sleep bruxism"), or while awake ("awake bruxism"). [11] This is the most widely used classification since sleep bruxism generally has different causes to awake bruxism, although the effects on the condition on the teeth may be the same ...
Mydriasis can be induced via modulation of adrenergic or cholinergic signalling. Drugs that can cause mydriasis include: Stimulants (typically monoaminergics) such as amphetamines, cocaine, MDMA, and mephedrone. Anticholinergics such as diphenhydramine, atropine, hyoscyamine, and scopolamine antagonize the muscarinic acetylcholine receptors in
Here, dentists and oral pain experts share tips to stop bruxism. If you wake up with sore teeth or tight jaw muscles, you might be grinding your teeth at night. Here, dentists and oral pain ...
Allergy medications may cause brain damage, increase dementia risk because of course they can, everything can. ... If you've ever popped a Benadryl or two to sleep through a long flight (or even ...
An FAA report found that between 2012 and 2016, diphenhydramine was the most common pharmaceutical known to cause impairment detected in post-mortem toxicology tests performed on someone who may have been in charge of the aircraft at the time of a fatal plane crash, specifically naming both Benadryl and Sominex. [65]
Oromandibular dystonia is characterized by involuntary spasms of the tongue, jaw, and mouth muscles that result in bruxism, or grinding of the teeth, and jaw closure. These conditions frequently lead to secondary dental wear as well as temporomandibular joint syndrome. In addition, problems with chewing, speaking, and swallowing may result from ...
Whereas teeth rarely come into contact during normal chewing, grinding of teeth may occur 1-4 hours in a 24-hour period, most often during sleep. The amount of pressure placed on teeth during functional habits is 140–550 kilopascals (20–80 psi), but the pressure can range from 2–20.7 megapascals (290–3,000 psi) during parafunctional habits.