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FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
The FXR was the base model with solid black paint and laced wheels. The FXRS was the deluxe model with two tone paint, lowered suspension, mag wheels and a backrest. The FXR chassis was essentially an FLT Tour Glide chassis with slightly bigger diameter frame tubes and a more conventional design around the steering head. [10]
Fragile X mental retardation syndrome-related protein 1 is a protein that in humans is encoded by the FXR1 gene. [5] [6] [7]The protein encoded by this gene is an RNA binding protein that interacts with the functionally similar proteins FMR1 and FXR2.
Super Glide II FXR 82 cu in (1,340 cc) 1982–1985 Sport Glide FXRT 82 cu in (1,340 cc) 1983–1993 Super glide II FXRS 82 cu in (1,340 cc) [4] 1982–1988 Low Glide ...
FXR may refer to: Farnesoid X receptor; Foxer, a World War II torpedo countermeasure; F. X. Reid, pseudonym of British computer science academic Mike W. Shields
The Evolution Big Twin saw a fifteen-year run in Harley-Davidson's Dyna, Softail, FXR, and Touring frames, although a limited number of Evolutions were used in the 2000 model year CVO FXR4, and 1999 FXR2 and FXR3 models. While the main case was only slightly modified from the previous Shovelhead engine, the top end was significantly improved.
FXR-dependent processes in liver and intestine were proposed as therapeutic targets in human diseases. [7] Obeticholic acid is the first FXR agonist to be used in human drug studies. [medical citation needed] The FDA has flagged cases of serious liver injury associated with the use of obeticholic acid. [8]
Fexaramine is an investigational compound which acts as an agonist of the farnesoid X receptor (FXR), which is a bile acid-activated nuclear receptor that controls bile-acid synthesis, conjugation and transport, as well as lipid metabolism through actions in the liver and intestine.
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