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Sterile alpha and TIR motif containing 1 Is an enzyme that in humans is encoded by the SARM1 gene. It is the most evolutionarily conserved member of the Toll/Interleukin receptor-1 (TIR) family. [5] [6] SARM1's TIR domain has intrinsic NADase enzymatic activity that is highly conserved from archaea, plants, nematode worms, fruit flies, and humans.
Activation of SARM1 is sufficient to collapse NAD + levels and initiate the Wallerian degeneration pathway. [44] The activity of SARM1 helps to explain the protective nature of the survival factor NMNAT2, as NMNAT enzymes have been shown to prevent SARM1-mediated depletion of NAD +. [46]
Selective androgen receptor modulators (SARMs) are a class of drugs that selectively activate the androgen receptor in specific tissues, promoting muscle and bone growth while having less effect on male reproductive tissues like the prostate gland.
The toll-interleukin-1 receptor (TIR) homology domain is an intracellular signaling domain found in MyD88, SARM1, interleukin-1 receptors, toll receptors and many plant R proteins. It contains three highly conserved regions, and mediates protein-protein interactions between the toll-like receptors (TLRs) and signal-transduction components. TIR ...
Examples of proteins that contain armadillo repeats include β-catenin, Sarm1 , [4] α-importin, [5] plakoglobin, [6] adenomatous polyposis coli (APC), [7] and many others. The term armadillo derives from the historical name of the β-catenin gene in the fruitfly Drosophila where the armadillo repeat was first discovered.
SARM1 is a Toll-like receptor protein and also functions as a intracellular NADase. [3] Under normal circumstances NADase activity are inhibited in the presence of NAD+, where NAD+ binds to armadillo/heat motifs (ARMs), which inhibits the dimerization of the toll-like receptor domain that activates the NADase activity. [3]
Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose, nicotinamide, nicotinamide riboside and niacin. [1] In humans, several enzymes use NMN to generate nicotinamide adenine dinucleotide (NADH). [1]
66454 Ensembl ENSG00000173614 ENSMUSG00000028992 UniProt Q9HAN9 Q9EPA7 RefSeq (mRNA) NM_001297778 NM_001297779 NM_022787 NM_133435 NM_001356357 RefSeq (protein) NP_001284707 NP_001284708 NP_073624 NP_597679 NP_001343286 Location (UCSC) Chr 1: 9.94 – 9.99 Mb Chr 4: 149.55 – 149.57 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nicotinamide mononucleotide adenylyltransferase 1 ...
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