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The use of gold compounds has decreased since the 1980s because of numerous side effects and monitoring requirements, limited efficacy, and very slow onset of action. Most chemical compounds of gold, including some of the drugs discussed below, are not salts, but are examples of metal thiolate complexes.
Sodium aurothiomalate (INN, known in the United States as gold sodium thiomalate) is a gold compound that is used for its immunosuppressive anti-rheumatic effects. [ 2 ] [ 3 ] Along with an orally-administered gold salt, auranofin , it is one of only two gold compounds currently employed in modern medicine.
Gold pentafluoride, along with its derivative anion, AuF − 6, and its difluorine complex, gold heptafluoride, is the sole example of gold(V), the highest verified oxidation state. [ 19 ] Some gold compounds exhibit aurophilic bonding , which describes the tendency of gold ions to interact at distances that are too long to be a conventional Au ...
Examples of metals used in treatment include: Platinum: Platinum based compounds have been shown to specifically affect head and neck tumors. These coordination complexes are thought to act to cross-link DNA in tumor cells (Figure 2). Gold: Gold salt complexes have been used to treat rheumatoid arthritis (Figure 3). The gold salts are believed ...
Template:Gold compounds This page was last edited on 4 January 2024, at 11:49 (UTC). Text is available under the Creative Commons Attribution-ShareAlike 4.0 License ...
Gold thioglucose features gold in the oxidation state of +I, like other gold thiolates. It is a water-soluble, non-ionic species that is assumed to exist as a polymer. [ 1 ] Under physiological conditions, an oxidation-reduction reaction leads to the formation of metallic gold and sulfinic acid derivative of thioglucose.
Sodium aurothiosulfate, or sanocrysin, is the inorganic compound with the formula Na 3 [Au(S 2 O 3) 2]·2H 2 O. It is the trisodium salt of the coordination complex of gold(I), [Au(S 2 O 3) 2] 3−. The dihydrate, which is colorless, crystallizes with two waters of crystallization. The compound has some medicinal properties as well as potential ...
Chloro(tetrahydrothiophene)gold(I), abbreviated (tht)AuCl, is a coordination complex of gold. Like the dimethyl sulfide analog , this compound is used as an entry point to gold chemistry. The tetrahydrothiophene ligand is labile and is readily substituted with other stronger ligands.