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Fenamic acid is a derivative of anthranilic acid, [18]: 235 which in turn is a nitrogen isostere of salicylic acid, which is the active metabolite of aspirin. [ 18 ] : 235 Several non-steroidal anti-inflammatory drugs , including mefenamic acid , tolfenamic acid , flufenamic acid , and meclofenamic acid are derived from fenamic acid or ...
The following NSAIDs are derived from fenamic acid, which is a derivative of anthranilic acid, [143]: 235 which in turn is a nitrogen isostere of salicylic acid, which is the active metabolite of aspirin. [143]: 235 [144]: 17
These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid. [2]: 235 [3]: 17 [2] Fenamic acid can be synthesized from 2-chlorobenzoic acid and can be converted into acridone. [4]
Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (NSAIDs), and is used to treat mild to moderate pain. [4] [5] Its name derives from its systematic name, dimethylphenylaminobenzoic acid. It was discovered and brought to market by Parke-Davis as Ponstel in the 1960s.
Folpet, a phthalimide, is a commercial fungicide. [3]Phthalimide is used as a precursor to anthranilic acid, a precursor to azo dyes and saccharin. [2]Alkyl phthalimides are useful precursors to amines in chemical synthesis, especially in peptide synthesis where they are used "to block both hydrogens and avoid racemization of the substrates". [4]
Other names in common use include anthranilate hydroxylase, anthranilic hydroxylase, and anthranilic acid hydroxylase. This enzyme participates in 3 metabolic pathways: benzoate degradation via hydroxylation, carbazole degradation, and nitrogen metabolism. It employs one cofactor, iron.
Avenanthramides consist of conjugates of one of three phenylpropanoids (p-coumaric, ferulic, or caffeic acid) and anthranilic acid (or a hydroxylated and/or methoxylated derivative of anthranilic acid). [5] Collins and Dimberg have used different systems of nomenclature to describe the Avenanthramides in their publications.
Tryptophane as well as anthranilic acid can act as a precursor. The second precursor molecule is either a hemiterpene or a monoterpene (e.g. secologanine in cinchona alkaloids). Literature