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Renin cleaves a decapeptide from angiotensinogen, a globular protein. The decapeptide is known as angiotensin I . Angiotensin I is then converted to an octapeptide , angiotensin II by angiotensin-converting enzyme (ACE), [ 9 ] which is thought to be found mainly in endothelial cells of the capillaries throughout the body, within the lungs and ...
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin-angiotensin-aldosterone system (RAAS)—also known as the renin-angiotensin-aldosterone axis—that increases the volume of extracellular fluid (blood plasma, lymph, and interstitial fluid) and causes arterial ...
Renin is secreted by renal juxtaglomerular cells and catalyses the conversion of angiotensinogen into angiotensin I which is the rate-limiting step in the production of angiotensin II. Angiotensin II induces hypertension and REN therefore requires tight expression control.
The juxtaglomerular cells in the afferent arteriole constrict, and juxtaglomerular cells in both the afferent and efferent arteriole decrease their renin secretion. These actions function to lower GFR. Further increase in sodium concentration leads to the release of nitric oxide, a vasodilating substance, to prevent excessive vasoconstriction. [13]
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The renin receptor binds renin and prorenin.Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I. [8]This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis.
Nourish yourself with some of the brain foods mentioned in this chapter. Set a plan for the day. If you do at least these four things, you’ll be well on your way to revving up your brain to ...
Renin inhibitors bind to the active site of renin and inhibit the binding of renin to angiotensinogen, which is the rate-determining step of the RAAS cascade. [21] Consequently, renin inhibitors prevent the formation of Ang I and Ang II.