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BBA – Molecular and Cell Biology of Lipids [15] ISSN 1388-1981: 12 5.228 Commenced 1998; continuation of BBA – Lipids and Lipid Metabolism (1965–98) and BBA – Specialized Section on Lipids and Related Subjects (1963–64) BBA – Molecular Basis of Disease [16] ISSN 0925-4439: 12 6.633 Commenced 1990 BBA – Molecular Cell Research [17]
In addition to host-derived factors, pharmacologic agents also have profound impact on MDSC. Chemotherapeutic agents belonging to different classes have been reported to inhibit MDSC. Although this effect may well be secondary to inhibition of hematopoietic progenitors, there may be grounds for search of selectivity based on long-known ...
The LIM provides a comprehensive explanation of the observed neuropathologies associated with the disease, including the lipid irregularities first described by Alois Alzheimer himself, and accounts for the wide range of risk factors now identified with AD (including old age, ApoE4, Aβ, brain trauma, high blood pressure, smoking, type 2 ...
AIRE is a transcription factor expressed in the medulla [broken anchor] (inner part) of the thymus. It is part of the mechanism which eliminates self-reactive T cells that would cause autoimmune disease. It exposes T cells to normal, healthy proteins from all parts of the body, and T cells that react to those proteins are destroyed.
There is some evidence from humans and animals that there are reduced levels of plasmalogens in the brain in neurodegenerative disorders including Alzheimer disease, Parkinson's disease, Niemann–Pick disease, type C, Down syndrome, and multiple sclerosis, it is not clear if this is causal or correlative. [20]
It is also associated with the occurrence of other conditions like hypotransferrinemia, [4] [5] liver dysfunction, [6] [7] bone and joint issues, diabetes mellitus, heart disease, hormone imbalances, porphyria cutanea tarda (PCT), infertility, stroke, [8] neurodegenerative and brain damages, [9] some cancers, venous and peripheral artery disease.
15-lipoxygenase 1 (), while best known for converting the 20 carbon polyunsaturated fatty acid, arachidonic acid, into a series of 15-hydroxylated arachidonic acid metabolites (see 15-hydroxyicosatetraenoic acid), actually prefers as its substrate the 18 carbon polyunsaturated fatty acid, linoleic acid, over arachidonic acid, converting it to 13-hydroperoxy-9Z,11E-octadecadienoic acid (13-HpODE).
Blood Cells, Molecules and Diseases is a peer-reviewed medical journal covering hematology. It was established in 1975 as Blood Cells and obtained its current title in 1995. The editor-in-chief is Mohandus Narla. It is published eight times per year by Elsevier.