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Xenotransplantation (xenos-from the Greek meaning "foreign" or strange [1] [2]), or heterologous transplant, is the transplantation of living cells, tissues or organs from one species to another. [3] Such cells, tissues or organs are called xenografts or xenotransplants .
Xenotransfusion (from Greek xenos-'strange, foreign'), a form of xenotransplantation, was initially defined as the transfer of blood from one species into the veins of another. [1] In most cases, it is a transfer of blood between a non-human animal and a human. However, further experimentation has been done between various non-human animal species.
Xenotransplantation is a cross-species tissue transplantation from animal to human. [10] [11] The development of blood vessel anastomosis opened the door for xenotransplantation during the 20th century, which led to numerous attempts in organ transplantations with tissues from nonhuman primates (NHPs).
It is a form of xenotransplantation. PDX models are used to create an environment that allows for the continued growth of cancer after its removal from a patient. In this way, tumor growth can be monitored in the laboratory, including in response to potential therapeutic options. [1]
Xenotransplantation; Historically, CBER was responsible for some therapeutic proteins, such as monoclonal antibodies. Control of these has been transferred to CDER. Some other drugs, such as certain anticoagulants and plasma volume expanders remain under the control of CBER.
Dhaniram Baruah is an Indian heart surgeon from Assam, known for his work in the field of xenotransplantation.He is popularly known as India's Pig Heart Doctor. [1] On 1 January 1997, he became the first heart surgeon in the world to transplant a pig's heart in a human body. [2]
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Stephanie Fae Beauclair [1] (October 14, 1984 – November 15, 1984), better known as Baby Fae, was an American infant born in 1984 with hypoplastic left heart syndrome.She became the first infant subject of a xenotransplant procedure and first successful infant heart transplant, receiving the heart of a baboon.