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MSI-H status raises the possibility of Lynch syndrome, but MSI-H can also occur in patients without Lynch Syndrome and confirmation of Lynch Syndrome requires testing germline DNA. Lynch syndrome is associated with MSI and increases the risk for colon, endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and ...
DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.
House, also known as House, M.D., is an American medical drama series which premiered on Fox on November 16, 2004. House was created by David Shore. The show follows Dr. Gregory House (Hugh Laurie), an irascible, maverick medical genius who heads a team of diagnosticians at the fictional Princeton-Plainsboro Teaching Hospital (PPTH) in New Jersey.
Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...
Amid Robert F. Kennedy Jr.’s push to improve healthcare as part of the Make America Healthy Again ... RFK Jr. confirmation put childhood vaccines in spotlight: MMR fact vs fiction. Show comments.
After losing a bet on a boxing match to Wilson, House sets out to prove the fighter he bet on (Kevin Phillips) lost due to an underlying medical condition. House also begins injecting himself with an experimental drug reported to regrow muscle in rats. The team treats a scientist, Dr. Lee for seizures and symptoms of radiation poisoning
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The episode is set from the viewpoint of House and Dr. Nolan (guest star Andre Braugher), looking into House's past week to try to work out why House is showing signs of being upset and unperceptive. During the session with Dr. Nolan, House recounts the case of a woman (guest star Zoe McLellan ) who arrives at the Princeton Plainsboro emergency ...