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JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
The metabolite N-(3-hydroxypentyl) JWH-018 was found to have toxic effects that its parent compound does not. [77] Some metabolites even appear to be cannabinoid antagonists. [78] Lastly, they may contain unwanted substances, be mislabeled, or contain different doses than advertised (in one analysis, a difference of one log unit was found). [77]
FUB-JWH-018 (also known as FUB-018) is a naphthoylindole-based synthetic cannabinoid, representing a molecular hybrid of JWH-018 and AB-FUBICA or ADB-FUBICA. [1] [2]
JWH-007 [5] Naphthoylindole: 9.5 ± 4.5: 2.9 ± 2.6: CB 2 (3.3x) JWH-009: Naphthoylindole >10000: 141 ± 14: CB 2 (>70x) JWH-011: Naphthoylindole: JWH-015 [5] Naphthoylindole: 164 ± 22: 13.8 ± 4.6: CB 2 (12x) JWH-016: Naphthoylindole: 22 ± 1.5: 4.3 ± 1.6: CB 2 (5.1x) JWH-018 [5] Naphthoylindole: 9 ± 5: 2.9 ± 2.6: CB 2 (3.1x) JWH-019 ...
Chemical structure of JWH-018, a simple naphthoylindole. Naphthoylindoles are a class of synthetic cannabinoids. [1] Pharmacology.
JWH-018 was banned by controlled substances act on December 21, 2012. Law enforcement officials in Canada asked Huffman to serve as a consultant and expert witness. He received numerous media queries and requests for analytical help from law enforcement officials.
In a human study, after 50 μg/kg smoked JWH-018 are delivered, one male and a female have their serum concentration of 8.1 and 10.2 μg/L respectively after 5 minutes, down to 4.6 and 6.1 μg/L after 15 minutes, suggesting the biological half-life of JWH-018 is short. 13 phase 1 metabolites are identified.
JWH cannabinoids are those discovered by John W. Huffman and his team. Pages in category "JWH cannabinoids" The following 56 pages are in this category, out of 56 total.