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JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
JWH-018 [5] Naphthoylindole: 9 ± 5: 2.9 ± 2.6: CB 2 (3.1x) JWH-019: Naphthoylindole: 9.8 ± 2: 5.55 ± 2: CB 2 (1.77x) JWH-020: Naphthoylindole: 128 ± 17: 205 ± 20: CB 1 (1.6x) JWH-030: Naphthoylpyrrole: 87 ± 3: 320 ± 127: CB 1 (3.7x) JWH-031: Naphthoylpyrrole: 399 ± 109: JWH-032: Naphthoylpyrrole >10000 >10000 — JWH-033 ...
JWH-018, JWH-073, CP 47,497 (and its homologues), and HU-210, as well as leonotis leonurus, have been all banned in Latvia since 2005. [128] After the first confirmed lethal case from the use of legal drugs in late 2013, parliament significantly increased the number of temporarily banned substances used in Spice and similar preparations.
An assortment of several designer drugs. Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.
Chemical structure of JWH-018, a simple naphthoylindole. Naphthoylindoles are a class of synthetic cannabinoids. [1] Pharmacology.
JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist [3] at both the CB 1 and CB 2 cannabinoid receptors. It is somewhat selective for the CB 1 subtype, with affinity at this subtype approximately 5× the affinity at CB 2 . [ 4 ]
HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol [2] by a group led by Raphael Mechoulam at the Hebrew University. [3] [4] [5] HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action. [6]
JWH cannabinoids are those discovered by John W. Huffman and his team. Pages in category "JWH cannabinoids" The following 56 pages are in this category, out of 56 total.