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Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. [1] It is recommended that it be taken together with diet and exercise. [ 1 ] It may be used with other antidiabetic medication . [ 1 ]
Side effects include weight gain and hypoglycemia. While the potential for hypoglycemia is less than for those on sulfonylureas, [citation needed] it is still a serious potential side effect that can be life-threatening. Patients on this medication should know the signs and symptoms of hypoglycemia and appropriate management.
Other side-effects are: gastrointestinal upset, headache and hypersensitivity reactions. The safety of sulfonylurea therapy in pregnancy is unestablished. Prolonged hypoglycemia (4 to 10 days) has been reported in children borne to mothers taking sulfonylureas at the time of delivery. [18]
It has a similar potency as glibenclamide (glyburide) in the class of medication known as sulfonylureas. Its structure is similar since it has a cyclic acyl group which replaces the latter's 2-methoxy-5-chlorobenzyl. [2] Same as glibenclamide, it is classified as a second-generation sulfonylurea.
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World map of infant mortality rates in 2017. Infant mortality is the death of an infant before the infant's first birthday. [1] The occurrence of infant mortality in a population can be described by the infant mortality rate (IMR), which is the number of deaths of infants under one year of age per 1,000 live births. [1]
The severity of the effects resulting from the hypoglycemic episode depend on the length of the hypoglycemic episode and how low the neonate's blood glucose levels drop during the episode. [7] Because glucose is an essential nutrient for the brain, untreated neonatal hypoglycemia causes irreversible damage to both the posterior , occipital and ...
Long term effects vary by the substance that the neonate gets exposed to but they most commonly have been shown to affect growth, behavior, cognitive function, vision problems, motor problems, language, academic achievement, otitis media (infection or inflammation of the middel ear), and predisposition to self utilization of drugs.