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For example, Shigella is a longstanding World Health Organization (WHO) target for vaccine development, and sharp declines in age-specific diarrhea/dysentery attack rates for this pathogen indicate that natural immunity does develop following exposure; thus, vaccination to prevent this disease should be feasible. The development of vaccines ...
Shigellosis, known historically as dysentery, is an infection of the intestines caused by Shigella bacteria. [1] [3] Symptoms generally start one to two days after exposure and include diarrhea, fever, abdominal pain, and feeling the need to pass stools even when the bowels are empty. [1]
It is sometimes listed as an explicit differential diagnosis of bacillary dysentery, as opposed to a cause. [6] Bacillary dysentery should not be confused with diarrhea caused by other bacterial infections. One characteristic of bacillary dysentery is blood in stool, [7] which is the result of invasion of the mucosa by the pathogen.
Shigella is a leading cause of bacterial diarrhea worldwide, with 80–165 million annual cases (estimated) [6] and 74,000 to 600,000 deaths. [ 6 ] [ 7 ] It is one of the top four pathogens that cause moderate-to-severe diarrhea in African and South Asian children.
Shigella dysenteriae is a species of the rod-shaped bacterial genus Shigella. [1] Shigella species can cause shigellosis (bacillary dysentery). Shigellae are Gram-negative, non-spore-forming, facultatively anaerobic, nonmotile bacteria. [2] S. dysenteriae has the ability to invade and replicate in various species of epithelial cells and ...
Toxic megacolon paralyzes bowel movements or causes passing gas. Reactive arthritis, which is the inflammation of joints [13] Hemolytic-uremic syndrome (HUS) is a complication that occurs when bacteria enter the digestive system and produce toxins to destroy red blood cells that may cause bloody diarrhea as a symptom.
Symptoms of Shiga toxin ingestion include abdominal pain as well as watery diarrhea. Severe life-threatening cases are characterized by hemorrhagic colitis (HC). [16] The toxin is associated with hemolytic-uremic syndrome. In contrast, Shigella species may also produce shigella enterotoxins, which are the cause of dysentery.
The invasion of the cells can trigger a mild form of diarrhea or dysentery, often mistaken for dysentery caused by Shigella species. The illness is characterized by the appearance of blood and mucus in the stools of infected individuals or a condition called colitis. [citation needed]
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