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  2. Hyaluronic acid - Wikipedia

    en.wikipedia.org/wiki/Hyaluronic_acid

    A 2020 meta-analysis found that intra-articular injection of high molecular weight HA improved both pain and function in people with knee osteoarthritis. [27] Hyaluronic acid has been used to treat dry eye. [28] Hyaluronic acid is a common ingredient in skin care products. Hyaluronic acid is used as a dermal filler in cosmetic surgery. [29]

  3. Sodium hyaluronate - Wikipedia

    en.wikipedia.org/wiki/Sodium_hyaluronate

    In normal skin, low-molecular weight hyaluronate (5 kDa) enhanced penetration into the epidermis. [17] Transepidermal water loss increased by 55.5% with low-molecular weight, and was reduced by 28% with crosslinked resilient, and by 16% with HMW. [18] Its efficacy against wrinkles has not been tested in clinical trials. [19]

  4. Microbial hyaluronic acid production - Wikipedia

    en.wikipedia.org/wiki/Microbial_hyaluronic_acid...

    HA production is affected regarding to yield and molecular weight by temperature. [32] HA production increases while bacterial cells are growing above 37°C. However, HA yield decreases while molecular weight is higher with fermentation under 32°C. [31]

  5. Small molecule - Wikipedia

    en.wikipedia.org/wiki/Small_molecule

    In molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons [1]) organic compound that may regulate a biological process, with a size on the order of 1 nm [citation needed]. Many drugs are small molecules; the terms are equivalent in the literature.

  6. Low-molecular-weight heparin - Wikipedia

    en.wikipedia.org/wiki/Low-molecular-weight_heparin

    Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications. [1] They are used in the prevention of blood clots and, in the treatment of venous thromboembolism ( deep vein thrombosis and pulmonary embolism ), and the treatment of myocardial infarction .

  7. Hemagglutinin (influenza) - Wikipedia

    en.wikipedia.org/wiki/Hemagglutinin_(influenza)

    HA is a homotrimeric integral membrane glycoprotein. It has C3 molecular symmetry. It is shaped like a cylinder, and is approximately 13.5 nanometres long. [17] [18] HA trimer is made of three identical monomers. Each monomer is made of an intact HA0 single polypeptide chain with HA1 and HA2 regions that are linked by 2 disulfide bridges.

  8. Heparin - Wikipedia

    en.wikipedia.org/wiki/Heparin

    Heparin and its low-molecular-weight derivatives (e.g., enoxaparin, dalteparin, tinzaparin) are effective in preventing deep vein thromboses and pulmonary emboli in people at risk, [24] [25] but no evidence indicates any one is more effective than the other in preventing mortality. [26]

  9. Glycosaminoglycan - Wikipedia

    en.wikipedia.org/wiki/Glycosaminoglycan

    The fourth class of GAG, hyaluronic acid (HA), is not sulfated and is synthesized by three transmembrane synthase proteins HAS1, HAS2, and HAS3. HA, a linear polysaccharide, is composed of repeating disaccharide units of →4)GlcAβ(1→3)GlcNAcβ(1→ and has a very high molecular mass, ranging from 10 5 to 10 7 Da. Each HAS enzyme is capable ...

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