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Cafestol is a natural compound found in unfiltered coffee that may benefit certain aspects of metabolic health. New research suggests that 6 milligrams of cafestol twice daily for 12 weeks might ...
Cafestol may act as an agonist ligand for the nuclear receptor farnesoid X receptor and pregnane X receptor, blocking cholesterol homeostasis. Thus cafestol can increase cholesterol synthesis. [6] Cafestol has also shown anticarcinogenic properties in rats. [7] Cafestol also has neuroprotective effects in a Drosophila fruit fly model of ...
Cholesterol control: Barley is a source of beta-glucan, a type of soluble fiber shown to assist with cholesterol reduction. Beta-glucan is thought to help reduce cholesterol by binding ...
It has unique benefits on cholesterol and blood sugars. A 2021 study in the European Journal of Clinical Nutrition found that oat beta-glucan meaningfully improved blood sugars and insulin ...
Cholesterol synthesis appears to occur mostly at night, [139] so statins with short half-lives are usually taken at night to maximize their effect. Studies have shown greater LDL and total cholesterol reductions in the short-acting simvastatin taken at night rather than the morning, [140] [141] but have shown no difference in the long-acting ...
The first statin drug available to the general public was lovastatin. Mevastatin has since been derivatized to the compound pravastatin, which is a pharmaceutical used in the lowering of cholesterol and preventing cardiovascular disease. In vitro, it has antiproliferative properties. [4]
“Therefore, a PIN1 inhibitor drug given in combination with a statin to reduce cholesterol production in the tumor cells and decrease circulating cholesterol produced by the liver might be a ...
The effects of rosuvastatin on low-density lipoprotein (LDL) cholesterol are dose-related. Higher doses were more efficacious in improving the lipid profile of patients with hypercholesterolemia than milligram-equivalent doses of atorvastatin and milligram-equivalent or higher doses of simvastatin and pravastatin.
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