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Tadalafil is available in several dosages, from a minimum dosage of 2.5mg (milligrams) all the way up to a 20mg per tablet, the maximum dose of tadalafil in 24 hours. Tadalafil 10mg: Typical ...
For instance, in clinical trials, 11 to 15 percent of men reported headaches from Cialis at a dose of 5 to 20 milligrams. In comparison, only three to six percent of men who took Cialis every day ...
Unlike other ED medications, such as Viagra® (sildenafil) and Levitra® (vardenafil), which work for four to five hours per dose, Cialis® (which contains the active ingredient tadalafil) is a ...
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Tadalafil is an annulated 2,5-diketopiperazine. [25] It is also a 1,2,3,4-tetrahydro-β-carboline. Tadalafil can be synthesized starting from (D)-tryptophan methyl ester and piperonal via a Pictet–Spengler reaction. This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring: [26]
Tadalafil (marketed as Cialis) is a PDE5 inhibitor used to treat erectile dysfunction [23] and pulmonary arterial hypertension. [24] It has a longer half life than sildenafil of 17.5 hours, allowing it to be taken once a day. [24] Tadalafil "daily" (5 mg) is also used for treatment of benign prostate hyperplasia. [25]
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