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Klotho is an enzyme that in humans is encoded by the KL gene. [5] The three subfamilies of klotho are α-klotho, β-klotho, and γ-klotho. [ 6 ] α-klotho activates FGF23 , and β-klotho activates FGF19 and FGF21 . [ 7 ]
BioViva was founded in 2015. [2] The CEO, Elizabeth Parrish, started the company by becoming the first person in human history to take gene therapies associated with lengthening lifespans in model organism, [3] she appeared at WIRED Health 2017 in London to discuss BioViva's testing of gene therapies targeting hallmarks of the ageing process.
There are mixed reports that GH or IGF-1 modulates the aging process in humans and about whether the direction of its effect is positive or negative. [167] Klotho [151] [168] and exerkines [156] (see above) like irisin [169] are being investigated for potential pro-longevity therapies.
Klotho may refer to Klotho (Greek mythology) or Clotho, one of the Moirai, or Fates, in Greek mythology; 97 Klotho, an asteroid; Klotho (biology), a membrane protein;
Clotho (/ ˈ k l oʊ θ oʊ /; Greek: Κλωθώ) or Klotho, is a mythological figure. She is the youngest goddess of the Three Fates or Moirai. In ancient Greek mythology, she spins the thread of human life, her sisters draw out and cut the thread. She also made major decisions, such as when a person was born, thus in effect controlling people ...
“While cold therapy can be beneficial in specific situations, morning cold plunges show no benefit,” says Laura Sommer, a doctor of physical therapy and owner of In Motion Physical Therapy.
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2309 56484 Ensembl ENSG00000118689 ENSMUSG00000048756 UniProt O43524 Q9WVH4 RefSeq (mRNA) NM_001455 NM_201559 NM_019740 NM_001376967 RefSeq (protein) NP_001446 NP_963853 NP_062714 NP_001363896 Location (UCSC) Chr 6: 108.56 – 108.68 Mb Chr 10: 42.06 – 42.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by ...