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In humans, HEVs are found in all secondary lymphoid organs (with the exception of spleen, where blood exits through open arterioles and enters the red pulp), including hundreds of lymph nodes dispersed in the body, tonsils and adenoids in the pharynx, Peyer's patches (PIs) in the small intestine, appendix, and small aggregates of lymphoid ...
The periarteriolar lymphoid sheaths (PALS) are typically associated with the arteriole supply of the spleen; they contain T lymphocytes. Lymph follicles with dividing B lymphocytes are located between the PALS and the marginal zone bordering on the red pulp. IgM and IgG2 are produced in this zone.
Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen [1] – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity) during a normal immune response ...
The efferent lymphatic vessel commences from the lymph sinuses of the medullary portion of the lymph nodes and leave the lymph nodes at the hilum, either to veins or greater nodes. It carries filtered lymph out of the node. Efferent lymphatic vessels are also found in association with the thymus and spleen. This is in contrast to afferent ...
The splenic lymph nodes are found at the splenic hilum and in relation to the tail of the pancreas (pancreaticolienal lymph nodes). [1] [2] Their afferents are derived from the stomach, spleen, and pancreas. The splenic lymph nodes empty into the suprapancreatic, infrapancreatic and omental lymph nodes, which then drain to the coeliac nodes and ...
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in the lymphoid follicles of lymph ...
Lymph nodes are important for the proper functioning of the immune system, acting as filters for foreign particles including cancer cells, but have no detoxification function. In the lymphatic system, a lymph node is a secondary lymphoid organ. A lymph node is enclosed in a fibrous capsule and is made up of an outer cortex and an inner medulla.
Follicular DCs are a non-migratory population found in primary and secondary follicles of the B cell areas of lymph nodes, spleen, and mucosa-associated lymphoid tissue (MALT). They form a stable network due to intercellular connections between FDCs processes and intimate interaction with follicular B cells.