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The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 98 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 99 ]
Triton X-100 is a commonly used detergent in laboratories. [5] Triton X-100 is widely used to lyse cells to extract protein or organelles, or to permeabilize the membranes of living cells. [6] Some applications include: Inactivation of lipid-enveloped viruses (e.g. HIV, HBV, HCV) in manufacturing of biopharmaceuticals; Industrial purpose ...
The AN/MPQ-64 Sentinel is an X-band electronically steered pulse-Doppler 3D radar system used to alert and cue Short Range Air Defense (SHORAD) weapons to the locations of hostile targets approaching their front line forces. It is currently produced by Raytheon Missiles & Defense.
Fresh normal plasma has all the blood coagulation factors with normal levels. If the problem is a simple factor deficiency, mixing the patient plasma 1:1 with plasma that contains 100% of the normal factor level results in a level ≥50% in the mixture (say the patient has an activity of 0%; the average of 100% + 0% = 50%). [3]
Phosphoinositide 3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more of the phosphoinositide 3-kinase (PI3K) enzymes, which are part of the PI3K/AKT/mTOR pathway .
Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...
The Raytheon Sentinel is a retired airborne battlefield and ground surveillance aircraft formerly operated by the Royal Air Force (RAF). While based on the Bombardier Global Express ultra long-range business jet, the prime contractor for the Sentinel was the American defence firm Raytheon, which supplied most of the mission systems and performed the integration work.
The LGM-35 Sentinel, also known as the Ground Based Strategic Deterrent (GBSD), is a future American land-based intercontinental ballistic missile system (ICBM) currently in the early stages of development. [3] [4] It is slated to replace all 450 Minuteman III missiles from 2029 through 2075. The Minuteman missiles are currently stationed in ...
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