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Levobunolol is the pure L-enantiomer of bunolol and has more than 60 times the pharmacological activity of D-bunolol. [3] It is used as the hydrochloride , which melts at 209 to 211 °C (408 to 412 °F) and is soluble in water and methanol and slightly soluble in ethanol .
Betaxolol is most commonly ingested orally alone or with other medications for the management of essential hypertension. [4] It is a cardioselective beta blocker, targeting beta-1 adrenergic receptors found in the cardiac muscle.
The British National Formulary (BNF) is a United Kingdom (UK) pharmaceutical reference book that contains a wide spectrum of information and advice on prescribing and pharmacology, along with specific facts and details about many medicines available on the UK National Health Service (NHS).
Concomitant administration of bambuterol with corticosteroids, diuretics, and xanthine derivatives (such as theophylline) increases the risk of hypokalemia (decreased levels of potassium in the blood).
[20] Clenbuterol is a growth-promoting drug in the β agonist class of compounds. It is not licensed for use in China, [21] the United States, [20] or the EU [22] for food-producing animals, but some countries have approved it for animals not used for food, and a few countries have approved it for therapeutic uses in food-producing animals.
[20] [21] Intravenously, α to β blockade ratio is 1:7. [19] [16] Thus, the labetalol can be thought to be a beta blocker with some α-blocking effects. [16] [18] [22] By comparison, labetalol is a weaker β-adrenergic receptor blocker than propranolol, and has a weaker affinity for α-adrenergic receptors compared to phentolamine. [19] [18]
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Melperone binds to the dopamine D 2 receptor, just like all other clinically utilized antipsychotics, but it does so with a very low affinity and hence may be liable to rapidly dissociate from the D 2 receptor hence potentially giving it the profile of an atypical antipsychotic.