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Seurat package from Satija lab further allows combining of the protein and RNA counts and performing clustering on both measurements, as well as doing differential expression analysis between cell clusters of interest. ADT quantification needs to take into account the differences between the antibodies.
Biclustering was originally introduced by John A. Hartigan in 1972. [7] The term "Biclustering" was then later used and refined by Boris G. Mirkin. This algorithm was not generalized until 2000, when Y. Cheng and George M. Church proposed a biclustering algorithm based on the mean squared residue score (MSR) and applied it to biological gene expression data.
Graph-based model s: a clique, that is, a subset of nodes in a graph such that every two nodes in the subset are connected by an edge can be considered as a prototypical form of cluster. Relaxations of the complete connectivity requirement (a fraction of the edges can be missing) are known as quasi-cliques, as in the HCS clustering algorithm .
The estimated cluster configurations can be post-processed in order to identify differentially expressed genes and for generating gene- and sample-wise dendrograms and heatmaps. [60] DiffSplice is a method for differential expression detection and visualization, not dependent on gene annotations. This method is supported on identification of ...
The average silhouette of the data is another useful criterion for assessing the natural number of clusters. The silhouette of a data instance is a measure of how closely it is matched to data within its cluster and how loosely it is matched to data of the neighboring cluster, i.e., the cluster whose average distance from the datum is lowest. [8]
Clustering high-dimensional data is the cluster analysis of data with anywhere from a few dozen to many thousands of dimensions.Such high-dimensional spaces of data are often encountered in areas such as medicine, where DNA microarray technology can produce many measurements at once, and the clustering of text documents, where, if a word-frequency vector is used, the number of dimensions ...
The standard algorithm for hierarchical agglomerative clustering (HAC) has a time complexity of () and requires () memory, which makes it too slow for even medium data sets. . However, for some special cases, optimal efficient agglomerative methods (of complexity ()) are known: SLINK [2] for single-linkage and CLINK [3] for complete-linkage clusteri
These correlations may be different in different clusters, thus a global decorrelation cannot reduce this to traditional (uncorrelated) clustering. Correlations among subsets of attributes result in different spatial shapes of clusters. Hence, the similarity between cluster objects is defined by taking into account the local correlation patterns.