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  2. Levomefolic acid - Wikipedia

    en.wikipedia.org/wiki/Levomefolic_acid

    Levomefolic acid (and folic acid in turn) has been proposed for treatment of cardiovascular disease [10] [11] and advanced cancers such as breast and colorectal cancers. [12] It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP , a metabolite of the drug fluorouracil .

  3. Folate deficiency - Wikipedia

    en.wikipedia.org/wiki/Folate_deficiency

    Signs of folate deficiency anemia most of the time are subtle. [4] Anemia (macrocytic, megaloblastic anemia) can be a sign of advanced folate deficiency in adults. [1] Folate deficiency anemia may result in feeling tired, weakness, changes to the color of the skin or hair, open sores on the mouth, shortness of breath, palpitations, lightheadedness, cold hands and feet, headaches, easy bleeding ...

  4. Folate - Wikipedia

    en.wikipedia.org/wiki/Folate

    The 2013–2014 survey reported that for adults ages 20 years and older, men consumed an average of 249 μg/day folate from food plus 207 μg/day of folic acid from consumption of fortified foods, for a combined total of 601 μg/day of dietary folate equivalents (DFEs because each microgram of folic acid counts as 1.7 μg of food folate).

  5. Folate isn’t just for pregnant women – we should all be ...

    www.aol.com/folate-isn-t-just-pregnant-050000498...

    Serves: 4. Prep time: 10 minutes | Cook time: 10 minutes. Ingredients:. 500g pasta. 1 tbsp olive oil. 280g kale. 3 cloves of garlic, chopped. 3 tbsp. water. 90g ...

  6. Cerebral folate deficiency - Wikipedia

    en.wikipedia.org/wiki/Cerebral_folate_deficiency

    One cause of cerebral folate deficiency is a mutation in a gene responsible for folate transport, specifically FOLR1. [ 2 ] [ 4 ] This is inherited in an autosomal recessive manner. [ 2 ] Other causes appear to be Kearns–Sayre syndrome [ 5 ] and autoantibodies to the folate receptor .

  7. Remethylation - Wikipedia

    en.wikipedia.org/wiki/Remethylation

    The remethylation process involves the enzyme methionine synthase (MS), which requires vitamin B 12 as a cofactor, and also depends indirectly on folate [1] and other B vitamins. A second pathway, which is usually restricted to liver and kidney in most mammals, involves betaine-homocysteine methyltransferase (BHMT) and requires trimethylglycine ...

  8. B vitamins - Wikipedia

    en.wikipedia.org/wiki/B_vitamins

    Folate acts as a co-enzyme in the form of tetrahydrofolate (THF), which is involved in the transfer of single-carbon units in the metabolism of nucleic acids and amino acids. THF is involved in purine and pyrimidine nucleotide synthesis, so is needed for normal cell division, especially during pregnancy and infancy, which are times of rapid growth.

  9. Antifolate - Wikipedia

    en.wikipedia.org/wiki/Antifolate

    As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. Both high-folate diets and supplemental ...