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The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. [5] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.
Effect of insulin on glucose uptake and metabolism. Insulin binds to its receptor (1), which starts many protein activation cascades (2). These include translocation of Glut-4 transporter to the plasma membrane and influx of glucose (3), glycogen synthesis (4), glycolysis (5) and triglyceride synthesis (6).
3645 23920 Ensembl ENSG00000027644 ENSMUSG00000005640 UniProt P14616 Q9WTL4 RefSeq (mRNA) NM_014215 NM_011832 RefSeq (protein) NP_055030 NP_035962 Location (UCSC) Chr 1: 156.84 – 156.86 Mb Chr 3: 87.7 – 87.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene. References ^ a b c GRCh38: Ensembl ...
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Bahasa Indonesia; Italiano; ... Insulin-like growth factor 2 receptor; K. Killer activation receptor; Killer-cell immunoglobulin-like receptor; L. Lamin B receptor;
Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood.With the exception of insulin, most GLP-1 receptor agonists (liraglutide, exenatide, and others), and pramlintide, all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
The receptor is a member of a family which consists of the insulin receptor and the IGF-2R (and their respective ligands IGF-1 and IGF-2), along with several IGF-binding proteins. IGF-1R and the insulin receptor both have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF ...