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Cimetidine, sold under the brand name Tagamet among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. [ 1 ] [ 9 ] [ 10 ] It is mainly used in the treatment of heartburn and peptic ulcers .
Unlike cimetidine, the first H 2 antagonist, famotidine has a minimal effect on the cytochrome P450 enzyme system and does not appear to interact with as many drugs as other medications in its class. Some exceptions include antiretrovirals such as atazanavir , chemotherapeutics such as doxorubicin , and antifungal medications such as itraconazole .
Antihistamines do not chemically inactivate or prevent the normal release of histamine. Clemastine does also act as FIASMA (functional inhibitor of acid sphingomyelinase). [10] Clemastine is rapidly absorbed from the gastrointestinal tract and peak plasma concentrations are attained in 2–4 hours. Antihistamines are thought to be metabolized ...
Index inducer or just inducer predictably induce metabolism via a given pathway and are commonly used in prospective clinical drug-drug interaction studies. [2]Strong, moderate, and weak inducers are drugs that decreases the AUC of sensitive index substrates of a given metabolic pathway by ≥80%, ≥50% to <80%, and ≥20% to <50%, respectively.
It also could be because women tend to have more body fat, and therefore have more to lose in the first place—or that they tend to be more insulin resistant, adds Dr. Kumar. Other Medications
[40] 5α-DHP is a major hormone in circulation of normal cycling and pregnant women. [ 41 ] Other enzymes compensate to a degree for the absent conversion of 5α-reductase, specifically with local expression at the skin of reductive 17β-hydroxysteroid dehydrogenase , and oxidative 3α-hydroxysteroid dehydrogenase and 3β-hydroxysteroid ...
“Pregnant women and women trying to conceive should be taking prenatal vitamins. The most important reason is the folate supplementation,” says s Shanna Levine, M.D. , primary care physician ...
There’s reason to be a bit wary about popping a gummy to see if it does work. Dr. Mickey Karram , a gynecologist and urogynecologist, notes that supplements in general are not regulated by the ...
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