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Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg; Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval. [45] Estradiol and norgestimate (Prefest; 1 mg / 90 μg) was previously available in the U.S. but was discontinued.
The brand version, Progesterone, is around $450 for 30 capsules without any discounts or insurance applied. [178] In comparison, Walgreens offers 30 capsules of 100 mg in the generic version for $51 without insurance or coupons applied. The brand name costs around $431 for 30 capsules of 100 mg. [179]
Progesterone pharmacokinetics by route [1] [2] Route Form Dose C max (ng/mL) T max (hours) t 1/2 (hours) Oral: Capsule: 200 mg: 4.3–11.7: 2–2.5? Sublingual: Tablet [a] 100 mg: 13.5: 1–4 ~6–7 Suspension: 100 mg: 17.6: 0.5–1? Vaginal: Tablet [a] 100 mg: 10.9: 6–7: 13.7 Capsule: 100 mg: 9.7: 1–3? Intramuscular injection: Oil solution ...
Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...