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To avoid toxicity and risk of side effects, FDA guidelines recommend an initial dose of methamphetamine at doses 5–10 mg/day for ADHD in adults and children over six years of age, and may be increased at weekly intervals of 5 mg, up to 25 mg/day, until optimum clinical response is found; the usual effective dose is around 20–25 mg/day.
Different ATS also have different toxic dose. Methamphetamine fatality from ATS have been reported after ingestion of a minimal dose of 1.3 mg/kg, while the estimated minimum lethal dose in a non-addicted adult is 200 mg. [14] [26] Generally, children are more likely to develop toxicity and have lower chances of developing tolerance. [14]
In contrast to methamphetamine and methcathinone, 4-MMA appears to produce minimal dopaminergic neurotoxicity in mice. [5] [6] Conversely, mephedrone shows no dopaminergic neurotoxicity at all in mice.
In 2021, about 1.6 million people ages 12 and up in the U.S. had a methamphetamine use disorder and 1.4 million had a cocaine use disorder, according to data from the Substance Abuse and Mental ...
3,4-Methylenedioxyamphetamine (MDA), sometimes referred to as sass, is an empathogen-entactogen, stimulant, and psychedelic drug of the amphetamine family that is encountered mainly as a recreational drug.
3,4-Methyl enedioxy methamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), [19] [20] is an empathogen–entactogenic drug with stimulant and minor psychedelic properties.
The opposite of an indication is a contraindication, [4] a reason to withhold a certain medical treatment because the risks of treatment clearly outweigh the benefits. In the United States, indications for prescription drugs are approved by the FDA. Indications are included in the Indications and Usage section of the Prescribing Information.
Levmetamfetamine, also known as l-desoxyephedrine or levomethamphetamine, and commonly sold under the brand name Vicks VapoInhaler among others, is an optical isomer of methamphetamine primarily used as a topical nasal decongestant. [2]