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A 2018 pooled analysis from three phase III, randomized, double-blind, placebo-controlled studies on usage for Opioid-Induced Constipation, found that the numbers of patients reporting adverse effects were similar in both the lubiprostone and placebo treatment groups for all opioid classes (P ≥ 0.125); however, gastrointestinal adverse ...
However, there may be some short-term side effects, such as diarrhea, nausea, bloating, vomiting, or stomach pain. Normally, these are manageable, but if used for weight loss, the side effects of ...
Metabolic alkalosis is the most common acid-base imbalance observed. [26] Other significant adverse effects include rhabdomyolysis , [ 26 ] steatorrhoea , [ 26 ] inflammation and ulceration of colonic mucosa, [ 26 ] pancreatitis , [ 26 ] [ 27 ] kidney failure , [ 26 ] [ 28 ] [ 29 ] factitious diarrhea [ 26 ] [ 30 ] and other problems. [ 26 ]
Uncommon side effects are nausea and vomiting. In sensitive individuals, such as the elderly or people with reduced kidney function, excess lactulose dosage can result in dehydration and electrolyte disturbances such as low magnesium levels. Ingestion of lactulose does not cause a weight gain because it is not digestible, with no nutritional value.
Constipation is the most common chronic gastrointestinal disorder in adults. Depending on the definition employed, it occurs in 2% to 20% of the population. [18] [58] It is more common in women, the elderly and children. [58] Specifically constipation with no known cause affects females more often affected than males. [59]
The bulky mass stimulates the intestinal muscles, speeding stool transit time through the colon. Results usually occur within 12 to 72 hours. Calcium polycarbophil will not work without increased fluid intake. Calcium polycarbophil has been marketed as an over-the-counter agent used for treating functional bowel disorder and as a bulk-producing ...
Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...
Studies have shown that milk and molasses enemas have a low complication rate when used in the emergency department [20] and are safe and effective with minimal side effects. [21] Mineral oil functions as a lubricant and stool softener, but may have side effects including rectal skin irritation and leakage of oil. [22]
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