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Megacolon can be associated with Chagas disease. [11] Chagas disease is caused by Trypanosoma cruzi, a flagellate protozoan transmitted by the assassin bug. Chagas disease can also be acquired congenitally, through blood transfusion or organ transplant, and rarely through contaminated food (for example garapa).
Toxic megacolon is an acute form of colonic distension. [2] It is characterized by a very dilated colon ( megacolon ), accompanied by abdominal distension ( bloating ), and sometimes fever , abdominal pain , or shock .
Ogilvie syndrome, or acute colonic pseudo-obstruction, is the acute dilatation of the colon in the absence of any mechanical obstruction in severely ill patients. [1]Acute colonic pseudo-obstruction is characterized by massive dilatation of the cecum (diameter > 10 cm) and right colon on abdominal X-ray.
Megaduodenum due to its duodenal ganglionitis is an unusual condition, Megaduodenum's similarity to megacolon and megaesophagus diseases can better explain the most plausible causes of it. [6] In addition, some theories state that megaduodenum can be associated with the following causes: post-vagotomy, vitamin deficiency, and collagen diseases. [7]
Another helpful test to diagnose this condition may be an abdominal X-ray as this can show the distribution of feces and show any abnormalities with the colon, for example a megacolon. [14] Methods used for diagnosis may vary depending on if the patient is ncontinent or constipated.
It may occur in chronic obstruction of stool transit, as in megacolon [10] and chronic constipation. Some diseases, such as Chagas disease, Hirschsprung's disease and others damage the autonomic nervous system in the colon's mucosa (Auerbach's plexus) and may cause extremely large or "giant" fecalomas, which must be surgically removed ...
Complications may include enterocolitis, megacolon, bowel obstruction and intestinal perforation. [1] [2] The disorder may occur by itself or in association with other genetic disorders such as Down syndrome or Waardenburg syndrome. [1] [2] About half of isolated cases are linked to a specific genetic mutation, and about 20% occur within ...
Goldberg-Shprintzen megacolon syndrome [1] Goldberg–Shprintzen syndrome is inherited in an autosomal recessive manner Goldberg–Shprintzen syndrome is a very rare connective tissue condition associated with mutations in KIAA1279 gene which encodes KIF-binding protein (KBP), a protein that may interact with microtubules and actin filaments .