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Clonazepam, sold under the brand name Klonopin among others, is a benzodiazepine medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, obsessive–compulsive disorder (OCD), and akathisia. [11] It is a long-acting [12] tranquilizer of the benzodiazepine class. [11]
Bleeding typically occurs during the placebo or sugar pill week, but if you’re trying to avoid a period, you would start your next pack right away, adds Dr. Brauer.
Chlordiazepoxide, which also has a long half-life and long-acting active metabolites, can be used as an alternative. [ 145 ] [ 146 ] Nonbenzodiazepines are contraindicated during benzodiazepine withdrawal as they are cross tolerant with benzodiazepines and can induce dependence. [ 15 ]
In the elderly, long-term benzodiazepine therapy is a risk factor for amplifying cognitive decline, [29] although gradual withdrawal is associated with improved cognitive status. [30] A study of alprazolam found that 8 weeks administration of alprazolam resulted in deficits that were detectable after several weeks but not after 3.5 years. [31]
Protracted symptoms continue to fade over a period of many months or several years. There is no known cure for protracted benzodiazepine withdrawal syndrome except time, [ 20 ] however, the medication flumazenil was found to be more effective than placebo in reducing feelings of hostility and aggression in patients who had been free of ...
Chlordiazepoxide has a medium to long half-life, while its active metabolite has a very long half-life. The drug has amnesic, anticonvulsant, anxiolytic, hypnotic, sedative, and skeletal muscle relaxant properties. [4] Chlordiazepoxide was patented in 1958 and approved for medical use in 1960. [5]
Written references to a "safe period" do not appear again for over a thousand years. [9] Scientific advances prompted a number of secular thinkers to advocate periodic abstinence to avoid pregnancy: [ 11 ] in the 1840s it was discovered that many animals ovulate during estrus .
Dysmenorrhea, also known as period pain, painful periods or menstrual cramps, is pain during menstruation. [ 4 ] [ 5 ] [ 2 ] Its usual onset occurs around the time that menstruation begins. [ 1 ] Symptoms typically last less than three days. [ 1 ]