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Pleocytosis, raised CSF protein level and positive CSF serology suggest neurosyphilis. [31] CSF VDRL is 50-90% specific for neurosyphilis. [18] 60% of newborns with congenital syphilis also have neurosyphilis. [18] Non-treponemal titers should be monitored in the newborns every 2-3 months to ensure an adequate response to treatment. [18]
Neurosyphilis is the infection of the central nervous system by Treponema pallidum, the bacterium that causes the sexually transmitted infection syphilis. In the era of modern antibiotics , the majority of neurosyphilis cases have been reported in HIV-infected patients.
Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.
Meningeal syphilis (as known as syphilitic aseptic meningitis or meningeal neurosyphilis) is a chronic form of syphilis infection that affects the central nervous system. Treponema pallidum , a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and can infect all its systems if not treated ...
Died by suicide on account of blindness caused by neurosyphilis. Leo Tolstoy (1828–1910), Russian writer Suspected to have had syphilis [9] Alphonse Daudet (1840–1897), French novelist Friedrich Nietzsche (1844–1900), German philosopher Cause of death disputed, but syphilis or mercury poisoning from syphilis treatment are leading theories.
The history of syphilis has been well studied, but the exact origin of the disease was the source of debate until archaeological and genetic evidence showed conclusively it originated in the Americas.
Syphilis cases by gender, transmission category and year in EU/EEA countries reporting consistently, 2012–2021. In 2021, twenty-eight EU/EEA countries reported 25,270 confirmed syphilis cases, giving an overall notification rate of 7.0 per 100,000 population, [14] up from 6.0 in 2015.
They are a highly specific sign of neurosyphilis; however, Argyll Robertson pupils may also be a sign of diabetic neuropathy. In general, pupils that accommodate but do not react are said to show light-near dissociation (i.e., it is the absence of a miotic reaction to light, both direct and consensual, with the preservation of a miotic reaction ...